Restrospective study of 25 patients with DRESS syndrome

Authors

  • Angélica María Trujillo Perdomo Dr. Federico Abete Trauma and Emergency Hospital, Malvinas Argentinas, Province of Buenos Aires, Argentina
  • Eliana E. Giangualano Dr. Federico Abete Trauma and Emergency Hospital, Malvinas Argentinas, Province of Buenos Aires, Argentina
  • Martina Vannelli Dr. Federico Abete Trauma and Emergency Hospital, Malvinas Argentinas, Province of Buenos Aires, Argentina
  • María Verónica Rossi Dr. Federico Abete Trauma and Emergency Hospital, Malvinas Argentinas, Province of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v29i2.2452

Keywords:

adverse reaction to drugs, DRESS, pharmacoderma

Abstract

DRESS syndrome is an acronym for drug reaction with eosinophilia and systemic symptoms, it is considered a rare and severe disease characterized by the presence of eosinophilia that comes with exanthema, facial edema, fever, lymphadenopathy, and liver compromise. It typically has a long evocative delay time. The medicines commonly involved are anticonvulsants, allopurinol, and antibiotics. Treatment consists of suspending the associated medication and, depending on the severity of skin and internal organ involvement, the use of corticosteroids. We conducted a descriptive, retrospective, and observational study of 25 clinical cases diagnosed with DRESS syndrome who were admitted to the Dr. Federico Abete Trauma and Emergency Hospital between June 2013 and November 2022. Clinical characteristics, drugs involved, and required treatment are described. Finally, a bibliographical review of the subject was developed. The search engines used were: Medline, Lilacs, Clinicalkey and Google Scholar.

Author Biographies

Angélica María Trujillo Perdomo, Dr. Federico Abete Trauma and Emergency Hospital, Malvinas Argentinas, Province of Buenos Aires, Argentina

Resident Physician, Dr. Federico Abete Trauma and Emergency Hospital

Eliana E. Giangualano, Dr. Federico Abete Trauma and Emergency Hospital, Malvinas Argentinas, Province of Buenos Aires, Argentina

Chief Resident, Dr. Federico Abete Trauma and Emergency Hospital

Martina Vannelli, Dr. Federico Abete Trauma and Emergency Hospital, Malvinas Argentinas, Province of Buenos Aires, Argentina

Dermatologist, Dr. Federico Abete Trauma and Emergency Hospital

María Verónica Rossi, Dr. Federico Abete Trauma and Emergency Hospital, Malvinas Argentinas, Province of Buenos Aires, Argentina

Head of the Dermatology Service, Dr. Federico Abete Trauma and Emergency Hospital

References

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Published

2023-08-29

Issue

Section

Original Articles