Hamartoma folicular basaloide linear unilateral con lesiones cutáneas y mucosas

Hugo N. Cabrera; Patricia Della Giovanna; Sandra García; Karina V. Nadur

Authors

Hugo N. Cabrera Prof. Dr. Alejandro Posadas National Hospital, El Palomar, Province of Buenos Aires, Argentina
Patricia Della Giovanna Prof. Dr. Alejandro Posadas National Hospital,Province of Buenos Aires, Argentina
Sandra García Prof. Dr. Alejandro Posadas National Hospital,Province of Buenos Aires, Argentina
Karina V. Nadur Faculty of Medicine, Buenos Aires' University, Autonomous City of Buenos Aires, Argentina

Keywords:

basaloid follicular hamartoma

Abstract

Basaloid follicular hamartoma is a rare bening malformation which may be clinically and histopathologically confused with basal cell carcinoma. Malignancy can occur, thus it is important to recognize it. We present a patient with a unilateral linear lesion clinically following Blashko lines, with an alopecic scalp plaque and ipsilateral oral lesions; this association was not previously reported in the consulted literature (Dermatol. Argent., 2013, 19(2): 100-105).

Author Biographies

Hugo N. Cabrera, Prof. Dr. Alejandro Posadas National Hospital, El Palomar, Province of Buenos Aires, Argentina

Consulting Professor, Dermatology Service

Patricia Della Giovanna, Prof. Dr. Alejandro Posadas National Hospital,Province of Buenos Aires, Argentina

Dermatology Service Physician

Sandra García, Prof. Dr. Alejandro Posadas National Hospital,Province of Buenos Aires, Argentina

Head of the Pathological Anatomy Section

Karina V. Nadur, Faculty of Medicine, Buenos Aires' University, Autonomous City of Buenos Aires, Argentina

Doctor of the Medical Specialist in Dermatology career, UBA

References

I. Mehregan A.H., Baker S. Basaloid follicular hamartoma: three cases with localized and systematized unilateral lesions, J. Cutan. Pathol., 1985, 12: 55-65.

II. Harman M., Inalöz H.S., Akdeniz S., Inalöz S.S. et ál. Congenital non-familial unilateral basaloid follicular hamartoma, J. Am. Acad. Dermatol., 1999, 13: 210-213.

III. Unden A.B., Zaphiropoulos P.G., Bruce K, Toftgård R. et ál. Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma, Cancer Res., 1997, 15-57: 2336-2340.

IV. Hellani A., Baghadadi H., Dabbour N., Almassri N., et ál. A novel PTCH1 germline mutation distinguished basal cell carcinoma from basaloid follicular hamartoma: a case report, J. Med. Case Reports, 2009, 3: 52.

V. Naeyaert J.M., Pauwel C., Geerts M.L., Verplancke P. CD-34 and Ki67 staining patterns of basaloid follicular hamartoma are different from those in fibroepithelioma of Pinkus and others variants of basal cell carcinomas, J. Cut. Pathol., 2001, 28: 538-540.

VI. Morohashi M., Sakamoto F., Takenouchi T., Hashimoto T. et ál. A case of localized follicular hamartoma: an ultrastructural and immunohistochemical study, J. Cutan. Pathol., 2000, 27: 191-198.

VII. Browstein M.H. Basaloid follicular hamartoma:solitary and multiple types, J. Am. Acad. Dermatol., 1992, 27 (Part. 1): 237-240.

VIII. Walsh N., Ackerman A.B. Basaloid follicular hamartoma: solitary and multiple types, J. Am. Acad. Dermatol., 1993, 29: 125-129.

XIX. Díaz Martínez B., Izquierdo Estirado M.J., Alramadan M., Menéndez Ramos F. et ál. Hamartoma folicular basaloide linear unilateral, Med. Cutan. Iber. Lat. Am., 2009, 37: 251-253.

XX. Wheeler C.E. Jr., Carroll M.A., Groben P.A., Briggaman R.A. et ál. Autosomal dominantly inherited generalized basaloid follicular hamartoma syndrome: report of a new disease in a North Carolina family, J. Am. Acad. Dermatol., 2000, 43: 189-206.

XXI. Katayama I., Hirayama M., Eishi K. Basaloid follicular hamartoma with eruptive milia and hypohidrosis: is there a pathogenic relationship?, Eur. J. Dermatol., 2003, 13: 505-508.

XXII. Pujol R.M., Nadal C., Matías-Guiu X., Peyrí J. et ál. Multiple follicular hamartomas with sweat gland and sebaceous differentiation, vermiculate atrophoderma, milia, hypotrichosis, and late development of multipla basal cell carcinomas, J. Am. Acad. Dermatol., 1998, 39: 853-857.

XXIII. Mascaró J.M. Jr., Ferrando J., Bombi J.A., Lambruschini N. et ál. Congenital generalizad follicular hamartoma associated with alopecia and cystic fibrosis of three siblings, Arch. Dermatol., 1995, 131: 454-458.

XIV. Brown A.C., Crounse R.G., Winkelmann R.K. Generalizad hair-follicle hamartoma: associated with alopecia, aminoaciduria and miastenia gravis, Arch. Dermatol., 1969, 99: 478-493.

XV. Ridley C.M., Smith N. Generalized hair follicle hamartoma associated with alopecia and myasthenia gravis: report of a second case, Clin. Exp. Dermatol., 1981, 6: 283-289.

XVI. Morton S., Stevens A., Powell R.J. Basaloid follicular hamartoma, total body hair loss and SLE, Lupus, 1998, 7: 207-209.

XVII.Lee M.W., Choi J.H., Moon K.C., Koh J.K. Linear basaloid follicular hamartoma on the Blaschko´s line of the face, Clin. Exp. Dermatol., 2005, 30: 30-34.