Polyarteritis nodosa in a patient with primary immunodeficiency

Authors

  • Camila Bo Francisco J. Muñiz Hospital, City of Buenos Aires, Argentina
  • Ludmila Rodríguez Francisco J. Muñiz Hospital, City of Buenos Aires, Argentina
  • Carla Chackelevicius Francisco J. Muñiz Hospital, City of Buenos Aires, Argentina
  • Karen Ginzburg Francisco J. Muñiz Hospital, City of Buenos Aires, Argentina
  • Viviana Leiro Francisco J. Muñiz Hospital, City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v31i1.2765

Keywords:

cutaneous polyarteritis nodosa, primary immunodeficiency

Abstract

Cutaneous polyarteritis nodosa is a rare type of vasculitis that affects small and medium-sized blood vessels. While sometimes associated with infections, inflammatory diseases, drugs, and malignant neoplasms, no relationship with immunodeficiencies has been found in reviewed literature. The pathophysiology of cutaneous polyarteritis nodosa is not completely understood, however, mediation by immune complexes is suggested. Clinically, it is characterized by the presence of livedo reticularis and erythematous and painful nodules that ulcerate. A case of cutaneous polyarteritis nodosa is presented in a patient with primary immunodeficiency

Author Biographies

Camila Bo, Francisco J. Muñiz Hospital, City of Buenos Aires, Argentina

Second-year attending physician, Dermatology Unit

Ludmila Rodríguez , Francisco J. Muñiz Hospital, City of Buenos Aires, Argentina

Staff Physician, Dermatology Unit

Carla Chackelevicius, Francisco J. Muñiz Hospital, City of Buenos Aires, Argentina

Immunologist, Dermatology Unit

Karen Ginzburg, Francisco J. Muñiz Hospital, City of Buenos Aires, Argentina

Chief Resident, Dermatology Unit

Viviana Leiro, Francisco J. Muñiz Hospital, City of Buenos Aires, Argentina

Head of Service, Dermatology Unit

References

I. Daoud MS, Hutton KP, Gibson LE. Cutaneous periarteritis nodosa: a clínico pathological study of 79 cases. Br J Dermatol. 1997;136:706-713.

II. Nakamura T, Kanazawa N, Ikeda T, et ál. Cutaneous polyarteritis nodosa: revisiting its definition and diagnostic criteria. Arch Dermatol Res. 2009;301:117-121.

III. Morgan AJ, Schwartz RA. Cutaneous polyarteritis nodosa: a comprehensive review. Inter J Dermatol. 2010;49:750-756.

IV. Kawakami T, Yamazaki M, Mizoguchi M, et ál. High titer of anti-phosphatidylserine- prothrombin complex antibodies in patients with cutaneous polyarteritis nodosa. Arthritis Rheum. 2007;57:1507-1513.

V. Luo Y, Alexander M, Gadina M, O'Shea JJ, et ál. JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition. J Allergy Clin Immunol. 2021;148:911-925.

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Published

2025-04-04

Issue

Vol. 31 No. 1 (2025): January-April

Section

Clinical Cases

License

Copyright (c) 2025 on behalf of the authors. Reproduction rights: Argentine Society of Dermatology

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