Disseminated histoplasmosis with mucocutaneous involvement in an immunocompetent patient

Authors

  • Candela Pagirys Austral University Hospital, Buenos Aires Province, Argentina
  • Berenice Fouces Austral University Hospital, Province of Buenos Aires, Argentina
  • Javier Anaya Austral University Hospital, Buenos Aires Province, Argentina
  • Corina Busso Austral University Hospital, Province of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v31i3.2971

Keywords:

histoplasma capsulatum, disseminated histoplasmosis, systemic mycosis

Abstract

Histoplasmosis is a systemic mycosis caused by the dimorphic fungus Histoplasma capsulatum. Primary infection is usually asymptomatic; however, disseminated disease may develop in people with compromised cellular immunity. We describe the case of a 79-year-old immunocompetent patient who developed disseminated histoplasmosis with prominent mucocutaneous involvement. We highlight the importance of clinical suspicion due to the marked lesional polymorphism of this entity.

Author Biographies

Candela Pagirys, Austral University Hospital, Buenos Aires Province, Argentina

Resident Physician, Dermatology Department

Berenice Fouces, Austral University Hospital, Province of Buenos Aires, Argentina

Staff Physician, Chief Resident, Dermatology Service

Javier Anaya, Austral University Hospital, Buenos Aires Province, Argentina

Staff Physician, Pathological Anatomy Service

Corina Busso, Austral University Hospital, Province of Buenos Aires, Argentina

Dermatologist, Head of the Dermatology Service

References

I. Gómez-Santana LV, Torre AC, Hernández BA, Volonteri VI, et ál. Mucocutaneous manifestations of infection by Histoplasma capsulatum in HIV-negative immunosuppressed patients. Actas Dermosifiliogr. 2018;109: e27-e32.

II. Francini B, Cánepa MC, Lamonica C, Capece P, et ál. Histoplasmosis diseminada. Una infección oportunista en pacientes con infección por VIH. Experiencia en el Hospital Nacional Prof. A. Posadas, 2011-2017. Rev Chil Infectol. 2018;35:671-679.

III. Chang P, Rodas C. Skin lesions in histoplasmosis. Clinics in Dermatology. 2012;30: 592-598.

IV. Negroni R. Manifestaciones cutaneomucosas de la histoplasmosis diseminada (histoplasmosis clásica o Histoplasma capsulatum). Dermatol Argent. 2008;14:104-112.

V. Hati A, Sen S, Mallick S, Das S. Disseminated histoplasmosis with oral and cutaneous manifestations in an immunocompetent patient. Indian J Dermatol. 2020; 65: 552.

VI. Babariya H, Gaidhane SA, Acharya S, Kumar S. Coccidioidomycosis and histoplasmosis in Iimmunocompetent individuals. A comprehensive review of clinical features, diagnosis, and management. Cureus. 2024;16:e68375.

VII. Galgiani JN, Kauffman CA. Coccidioidomycosis and histoplasmosis in immunocompetent persons. N Engl J Med. 2024;390:536-47.

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Published

2025-12-01

Issue

Vol. 31 No. 3 (2025): September-December

Section

Clinical Cases

License

Copyright (c) 2025 on behalf of the authors. Reproduction rights: Argentine Society of Dermatology

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